Firms have been urged to test new working arrangements ahead of this summer's Olympic Games in a bid to avoid transport chaos.
With more people working from home, the TUC said flexitime and other arrangements should be considered to help ease pressure on transport systems, especially in London, in the coming months.
A study by the union organisation showed one in five people over the age of 55 already work from home as part of a growing trend.
But more people would like to have the chance of working from home, said the TUC report, published to mark National Work From Home Day, run by Work Wise.
TUC general secretary Brendan Barber said: "The Olympics are an ideal opportunity for more employers to try out innovative flexible working practices such as flexitime and home working.
"There is a huge demand from staff for more flexible working practices but too often they are held back by out-of-date attitudes and a lack a trust from bosses.
"But everyone can benefit from modernising the workplace. Working from home can help workers cut out the stressful and expensive commute. Employers who have already taken the plunge have gained improved productivity and staff motivation, and it will also reduce congestion and help the Olympics to run smoothly.
"With just 70 days left until the opening ceremony employers still have time to plan smarter working practices, but there is now a sense of urgency."
Charles Elvin, chief executive of the Institute of Leadership and Management, said: "With the Olympics now just 70 days away, many London- and South East-based businesses will be looking for ways to avoid rush hour commuting and businesses should seize this opportunity to trial home or other flexible working options to see how the business can operate remotely."
Travel firm Travel Counsellors supported the TUC's call, saying flexible working could boost productivity and increase staff wellbeing.